Linkage disequilibrium (LD)
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- Linkage disequilibrium (LD)search for term
Non-random association of alleles at two or more loci, determined by their individual and joint frequencies. LD between loci decreases with their recombinational distance. (Langridge 2010). The pattern and extent of linkage disequilibrium in a genomic region is affected by mutation, recombination, genetic drift, natural selection and demographic history. (Barrett 2011). This association is usually measured with a metric called r2 that ranges between zero (no linkage) and one (complete linkage). (Fan 2006)
