@article {73744,
	title = {The coffee genome provides insight into the convergent evolution of caffeine biosynthesis.},
	journal = {Science (New York, N.Y.)},
	volume = {345},
	year = {2014},
	month = {2014 Sep 5},
	pages = {1181-4},
	abstract = {Coffee is a valuable beverage crop due to its characteristic flavor, aroma, and the stimulating effects of caffeine. We generated a high-quality draft genome of the species Coffea canephora, which displays a conserved chromosomal gene order among asterid angiosperms. Although it shows no sign of the whole-genome triplication identified in Solanaceae species such as tomato, the genome includes several species-specific gene family expansions, among them N-methyltransferases (NMTs) involved in caffeine production, defense-related genes, and alkaloid and flavonoid enzymes involved in secondary compound synthesis. Comparative analyses of caffeine NMTs demonstrate that these genes expanded through sequential tandem duplications independently of genes from cacao and tea, suggesting that caffeine in eudicots is of polyphyletic origin.},
	keywords = {Caffeine, Coffea, Evolution, Molecular, Genome, Plant, Methyltransferases, Phylogeny, Plant Proteins},
	issn = {1095-9203},
	doi = {10.1126/science.1255274},
	author = {Denoeud, France and Carretero-Paulet, Lorenzo and Dereeper, Alexis and Droc, Ga{\"e}tan and Guyot, Romain and Pietrella, Marco and Zheng, Chunfang and Alberti, Adriana and Anthony, Fran{\c c}ois and Aprea, Giuseppe and Aury, Jean-Marc and Bento, Pascal and Bernard, Maria and St{\'e}phanie Bocs and Campa, Claudine and Cenci, Albero and Combes, Marie-Christine and Crouzillat, Dominique and Da Silva, Corinne and Daddiego, Loretta and de Bellis, Fabien and Dussert, St{\'e}phane and Garsmeur, Olivier and Gayraud, Thomas and Guignon, Valentin and Jahn, Katharina and Jamilloux, V{\'e}ronique and Jo{\"e}t, Thierry and Labadie, Karine and Lan, Tianying and Leclercq, Julie and Lepelley, Maud and Leroy, Thierry and Li, Lei-Ting and Librado, Pablo and Lopez, Loredana and Mu{\~n}oz, Adriana and Noel, Benjamin and Pallavicini, Alberto and Perrotta, Gaetano and Poncet, Val{\'e}rie and Pot, David and Pot, David and Rigoreau, Michel and Rouard, Mathieu and Rozas, Julio and Tranchant-Dubreuil, Christine and VanBuren, Robert and Zhang, Qiong and Andrade, Alan C and Xavier Argout and Bertrand, Beno{\^\i}t and de Kochko, Alexandre and Graziosi, Giorgio and Henry, Robert J and Henry, Robert J and Ming, Ray and Nagai, Chifumi and Rounsley, Steve and Sankoff, David and Giuliano, Giovanni and Albert, Victor A and Wincker, Patrick and Lashermes, Philippe}
}
